Thursday, January 11, 2018

Visionary Speaker: Matthew O’Donnell, Ph.D., University of Washington

What Will it Take for Photoacoustic Imaging to be Used Routinely in the Clinic?

Abstract: With recent developments in molecular-scale bioconjugated contrast agents and integrated system design, photoacoustics (PA) is rapidly bringing molecular sensitivity to ultrasound (US) imaging for many biomedical applications. The same agents can potentially be used for molecularly-targeted therapies as well, opening the possibility for molecular theranostics using integrated photoacoustics/ultrasonics (PAUS). In this presentation, we will explore a class of nanoemulsion-based contrast agents that can potentially be used for photoacoustic imaging, ultrasonic imaging, and molecularly-targeted therapies combining light/ultrasound excitation. In particular, excitation techniques have been developed exploiting the non-linear characteristics of the nanoemulsions to provide both high sensitivity and specificity for molecular imaging and therapy. Finally, a system capable of integrated PAUS imaging at real-time frame rates will be presented that can monitor molecular theranostic procedures enabled by these nanoemulsions.

Biography: Dr. O’Donnell is renowned for his interdisciplinary focus, including research work in the field of ultrasound at institutions such as the University of Notre Dame, the University of Michigan and currently, as Dean Emeritus of engineering at The University of Washington.  As an expert in ultrasound imaging, his research has resulted in more than 300 publications and numerous awards including the Achievement Award from the IEEE-UFFC Society and membership to the National Academy of Engineering.  Previously, Dr. O’Donnell served as part of General Electric’s corporate research team at their research and development center.

Poster session hosted by the Medical Imaging Training Program and the Center for in Vivo Microscopy.

Wednesday, November 16, 2016

Visionary Speaker: Kim Butts Pauly, Ph.D., Stanford University

MRI-guided Focused Ultrasound: Ablation to BBB opening to Neuromodulation

Abstract: Using a large area transducer, ultrasound can be focused deep into the body without any damage to intervening tissue. In ablative applications in the brain, MRI is used for targeting and for monitoring tissue temperature. It is important to assess that an effective temperature rise is achieved at the target, without heating nearby tissue. I will describe our MR thermometry methods that are robust to patient motion. Another important application of focused ultrasound is opening the blood-brain barrier for the delivery of therapeutics, such as chemotherapy and antibodies. In ultrasound-based neuromodulation, the brain is directly stimulated, eliciting behavior such as limb twitches in rodents. For both these applications, I will describe our work to calibrate the beam pressure with patient-specific CT-based simulation and MR acoustic radiation force imaging.

Biography: Kim Butts Pauly obtained a B.S. in Physics from Duke University. She received a Ph.D. from the Mayo Graduate School where she studied diagnostic MRI physics.  After a short postdoc at Stanford, she joined the faculty in the Department of Radiology at Stanford in 1996. Her work is currently focused on MRI-guided focused ultrasound in applications ranging from cancer treatment to functional disorders. She currently has courtesy appointments in both Biomedical Engineering and Electrical Engineering and is division chief for the Radiological Sciences Laboratory within Radiology.

The 2016 Imaging Technology Fair, which was co-sponsored with the Center for In Vivo Microscopy, included a talk by Visionary Seminar speaker, Dr. Kim Butts-Pauly, Professor of Radiology at Stanford University. Dr. Butts-Pauly's current research includes MRI-guided focused ultrasound in applications ranging from cancer treatment to functional disorders.

A poster session and reception followed Dr. Butts-Pauly's seminar. Over 20 graduate students and post-docs were on-hand at the poster session to highlight their medical imaging-related research.

Thursday, October 8, 2015

The 2015 Imaging Technology Fair was co-sponsored with the Center for In Vivo Microscopy and opened with a lecture by Visionary Seminar speaker, Bill Walker, Ph.D. Dr. Walker is Founder and CTO of HemoSonics and holds a position as Adjunct Professor in Duke's Department of Biomedical Engineering.

A poster session and reception followed Dr. Walker's lecture in which Duke's graduate students and post-docs showcased their amazing research within the medical imaging technology field.

Wednesday, October 15, 2014

The 2014 Imaging Technology Fair highlighted the exciting contributions of some of our younger faculty, and informed the basic and clinical science communities about the extraordinary imaging resources available at Duke. A poster session showcasing top-notch research being conducted by Duke graduate students and post-docs followed the lectures. The reception included an award ceremony for best posters.

Speakers

• Alexandra Badea (CIVM): Quantitative Phenotyping Based on Small Animal Imaging
• Sina Farsiu (BME/Ophthalmology): Smart Clinical Imaging and Image Processing
• Chunlei Liu (Brain Imaging & Analysis Center): Susceptibility Imaging
• Anthony Kuo (Ophthalmology): Optical Coherence Tomography of the Eye: Applications for Clinical Metrology and Surgery
• Mark Palmeri (BME): Ultrasonic Tissue Elasticity Imaging: Numerical, Experimental and Clinical Development
• Thomas Theis (Chemistry): Hyperpolarization Techniques and Long-lived Spin States for Molecular MR